A disaccharide is an elementary form of carbohydrate that is necessary for the intricate web of metabolic processes that keep life alive. These molecules constitute the combination of two monosaccharide […]
Covalent inhibitors generally refer to irreversible covalent inhibitors; however, in detailed studies, they can be divided into irreversible covalent inhibitors (ICIs) and reversible covalent inhibitors (RCIs). Advantages of covalent inhibitors […]
The target spectrum and treatable diseases of small nucleic acid drugs are diverse. Relevant companies primarily focus on rare monogenic diseases with clear pathogenic mechanisms, well-defined biomarkers, and a lack […]
Molecular Glue refers to small molecules, typically smaller than PROTACs, often with improved physicochemical properties, designed to stabilize interactions between two proteins. In most cases, this approach is used to enhance […]
In the process of small molecule drug development, lipophilicity (or hydrophobicity) is a very important indicator that has a crucial impact on pharmacokinetics and pharmacodynamics. Lipophilicity involves the pharmacokinetic processes […]
mRNA therapeutics is a newly emerging form in recent years. Its basic principle is to introduce mRNA expressing antigen targets into the body through specific delivery systems, express protein antigens […]
Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in cells participate in nearly all life […]
The preparation of amides is one of the most common reactions in organic synthesis and a key reaction for the preparation of peptide drugs and nucleic acid drugs in recent years. […]
The Drug-to-Antibody Ratio (DAR) is the most important quality attribute of ADC drugs because it determines the “payload” that can be delivered to tumors, directly impacting safety and efficacy. Here, we […]
In the early 21st century, after the completion of the Human Genome Project, it was discovered that many diseases were caused by gene mutations leading to insufficient expression of functional […]