Exatecan Mesylate is a semi-synthetic water-soluble derivative of camptothecin. It is a new type of topoisomerase I inhibitor with anti-tumor activity. The anhydrous, alkali-free form of the drug is called […]
Maintenance of DNA topology is critical for normal DNA replication, transcription and repair in eukaryotic cells. One family of enzymes, the topoisomerases, is essential for this process. Eukaryotic topoisomerase I […]