PROTACs

New PROTAC Technology

New PROTAC Technology

Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in cells participate in nearly all life […]

protac design

PROTACs Design Strategy: CRBN Ligand Modification

PROTACs, a novel therapeutic approach, have garnered interest from numerous pharmaceutical companies, including Merck, Genentech, Pfizer, Novartis, Arvinas, C4 Therapeutics, Haisco Pharmaceutical, Kintor Pharmaceutical, and BeiGene. Currently, approximately 20 PROTACs […]

ligands in PROTACs

Thalidomide Analogs and Other CRBN Ligands in PROTACs

History of Thalidomide During the 1950s-1960s, thalidomide was widely used as an antiemetic for pregnant women, leading to a tragic outcome with thousands of cases of malformed babies. However, in 1965, […]

PROTAC drug discovery

Metabolic Characteristics of PROTAC Drugs

1. Structural Characteristics of PROTAC PROTAC consists mainly of three key structures: on one side is the ligand structure targeting the Protein of Interest (POI); on the other side is […]

Review of Targeted Protein Degradation (TPD) Technology

Review of Targeted Protein Degradation (TPD) Technology

Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been discovered against more than […]