Oligonucleotide

oligonucleotide drugs

Hybridization-ELISA in the Bioassay of Oligonucleotide Drugs

Introduction of Oligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), […]

Oligonucleotide Drug Development

Current Status and Prospects of Oligonucleotide Drug Development

As an important drug modality, the development of oligonucleotides will continue to expand in the coming years. Oligonucleotide drugs are a class of therapeutic agents composed of short nucleotide sequences […]

DNA

FDA Approved Oligonucleotide Drugs

Why oligonucleotide drugs? Synthetic oligonucleotides are the key factor in almost all molecular biological methodologies. They are used in PCR, reverse transcription, sequencing, gene editing, synthetic biology, cloning, single nucleotide […]

Application model of ASO and RNAi therapy in metabolic diseases

What are Oligonucleotide Therapies?

Oligonucleotides are short synthetic DNA or RNA polymers, which modulate gene expression through Watson-Crick base pairing with targeted nucleic acids. Oligonucleotides regulate gene expression through a series of processes, including […]

Strategies to Enhance Oligonucleotide Drug Delivery

1. Chemistry Modification Chemical modification represents one of the most effective approaches to enhance oligonucleotide drug delivery. Modification of the nucleic acid backbone, the ribose sugar moiety and the nucleobase […]