Linaclotide

Linaclotide, Novel Therapy for the Treatment of Chronic Idiopathic Constipation

Linaclotide, Novel Therapy for the Treatment of Chronic Idiopathic Constipation

Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are common gastrointestinal (GI) disorders. The overall prevalence of CC in the general population is approximately 20%. CC is defined by infrequent bowel movements (less […]

Linaclotide Management of Difficult Constipation

Linaclotide Management of Difficult Constipation

Linaclotide is a 14-amino acid peptide that stimulates intestinal guanylate cyclase type-C (GC-C) receptors. Linaclotide is acid stable and protease resistant with low bioavailability; it is undetectable in the systemic circulation […]