Inhibitor

SARS

Progress in R&D of Small Molecule Anti-COVID-19 Drugs (2)

Facing the Coronavirus with continuous mutations, researchers are working hard to develop effective and broad-spectrum anti-Coronavirus drugs and vaccines. At the end of 2021, the small molecule oral drug was […]

SARS

Progress in R&D of Small Molecule Anti-COVID-19 Drugs (1)

The Coronavirus outbreak has posed a great threat to human health. Facing the continuous mutation of Coronavirus, researchers are working hard to develop effective and broad-spectrum anti-COVID-19 drugs as well […]

IDO1 inhibitors

Recently Disclosed IDO1 Inhibitors

Abnormally high expression of indoleamine 2, 3-dioxygenase 1 (IDO1) is closely related to tumor immune escape and is an important target of tumor immunotherapy. In-depth research on the structure and […]

Imidazoline quinolones

Advances in mTOR Inhibitors

A mass of studies have revealed that mTOR is a serine/threonine protein kinase closely related to the occurrence of A mass of studies have revealed that mTOR is a serine/threonine […]

drug

Approved Carbohydrate-based Drugs During 2000-2021

As the basic substance of life, carbohydrate molecules participate in almost all aspects of life activities and play various important biological functions. Based on the extensive biological functions of carbohydrate, […]

The Development of Small-molecule Inhibitors Targeting CD47

The Development of Small-molecule Inhibitors Targeting CD47

Abstract Immunotherapy has become an indispensable part of cancer treatment. A pivotal phagocytosis checkpoint, named cluster of differentiation 47 (CD47), which functions as a ‘don’t eat me’ signal to protect […]

Insight the Trends and Future Directions, From FDA-Approved Drugs in The Past Decades (2010-2019)

Insight the Trends and Future Directions, From FDA-Approved Drugs in The Past Decades (2010-2019)

In the latest issue of the JMC journal, a review article, entitled “A Decade of FDA-Approved Drugs (2010-2019): Trends and Future Directions”, was published, which analyzed and summarized the FDA-approved […]

New Drug Report 2020 -4

New Drug Report 2020 -4

05 Cardiovascular system drugs The sodium-glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin (Andaton; AstraZeneca) has been on the market as a hypoglycemic agent for nearly 10 years. Another indication of the […]

Exploring the Future Direction of Antibacterial Drugs

Exploring the Future Direction of Antibacterial Drugs

The birth of penicillin in 1943 opened the golden age of antimicrobial therapy. However, after the 1980s, large pharmaceutical companies faced major scientific challenges in finding new antibiotics to solve […]

What is Exatecan Mesylate?

What is Exatecan Mesylate?

Exatecan Mesylate is a semi-synthetic water-soluble derivative of camptothecin. It is a new type of topoisomerase I inhibitor with anti-tumor activity. The anhydrous, alkali-free form of the drug is called […]