Constipation

Linaclotide Management of Difficult Constipation

Linaclotide Management of Difficult Constipation

Linaclotide is a 14-amino acid peptide that stimulates intestinal guanylate cyclase type-C (GC-C) receptors. Linaclotide is acid stable and protease resistant with low bioavailability; it is undetectable in the systemic circulation […]