Introduction to HER and ADCs Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play a core role in regulating cell proliferation, […]
On July 17, 2017, the U.S. Food and Drug Administration approved neratinib (Nerlynx, Puma Biotechnology, Inc.) for the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer to […]
The concept of arming antibodies by conjugation to protein toxins dates back to 1970, and was followed a few years later by antibody conjugates with cytotoxic drugs. Antibody therapeutics have come of age […]
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