antibody-drug conjugates

drugs

List of ADCs Targeting HER

Introduction to HER and ADCs Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play a core role in regulating cell proliferation, […]

FDA Approves Neratinib for Extended Adjuvant Treatment of Breast Cancer

On July 17, 2017, the U.S. Food and Drug Administration approved neratinib (Nerlynx, Puma Biotechnology, Inc.) for the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer to […]

Antibody-drug conjugates

Antibody-drug conjugates

The concept of arming antibodies by conjugation to protein toxins dates back to 1970, and was followed a few years later by antibody conjugates with cytotoxic drugs. Antibody therapeutics have come of age […]