The World Health Organization (WHO) reported on December 12, 2017 that there are approximately 50 million people with dementia worldwide, of which nearly 60% are living in low- and middle-income […]
December 7, 2017 – Researchers from Brock University have found that certain amounts of lithium in drinking water may slow death rates in people with Alzheimer’s disease, according to a […]
Caffeine boosts enzyme that could protect against dementia A study by Indiana University researchers has identified 24 compounds – including caffeine – with the potential to boost an enzyme in […]
How to Prevent Dementia? (Part One) Memory loss is one striking feature of dementia. So, if you feel your memory gets worse and worse, then be cautious! That might be warning […]
Since Ed Hall and colleagues first discovered that female gerbils were relatively protected from global cerebral ischemia, compared with their male counterparts, in the early 1990s (Hall et al., 1991), gender differences […]
γ-Secretase is a multi-subunit protein complex that is composed of at least four proteins-Presenilin (PS), Nicastrin (Net), Presenilin-enhancer 2 (Pen2) and Anteriorpharyx defective (Aph). These four subunits form an active γ-Secretase complex in the […]
The clinical symptoms and signs of Alzheimer’s disease (AD) result from abnormalities associated with neuronal dysfunction and cell death in specific brain regions which are important in memory and cognitive functions. Damaged circuits include […]
Alzheimer’s disease (AD), the most common type of dementia is a progressive neurodegenerative disorder characterized by a decline in cognitive function and memory impairment. Characteristic neuropathological features of AD are accumulation of amyloid […]
The presence of amyloid deposits in the brain is one of the major histopathological characteristics of Alzheimer’s disease (AD). The amyloid cascade hypothesis proposes that the amyloid -peptide (Aβ), a major component […]
The “cholinergic hypothesis” proposes that part of age-related cognitive decline is caused by reduced cerebral cholinergic function. This theory has been used as a rationale for testing drug therapies that restore cholinergic function […]
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