Antibody-Drug Conjugates (ADCs) are new therapies that combine the high targeting of monoclonal antibodies with the strong cytotoxicity of small molecule cytotoxins. Due to its precise and powerful mechanism of action, […]
PEG-Lipid derivatives have the advantages of increasing the stability of liposomes, extending the half-life of blood circulation, improving tumor targeting efficiency and enhancing drug efficacy. In-depth study of the effects of […]
It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB). This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a […]
This article covers the latest developments in natural product research, primarily including ribosomally synthesized peptides, sesquiterpenes, diterpenes, and triterpenes. 1. Discovery of two novel terpenoid skeletons rapidly from Daphne altaica Pall. Using GNPS […]
As an important drug modality, the development of oligonucleotides will continue to expand in the coming years. Oligonucleotide drugs are a class of therapeutic agents composed of short nucleotide sequences […]
Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came […]
In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell’s own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from […]
Cancer immunotherapy holds enormous potential in combating malignant tumors. Messenger ribonucleic acid (mRNA) has emerged as a widely studied tool in recent years, functioning within the cytoplasm and eliminating the […]
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is associated with the […]
Alzheimer’s disease (AD) is a very common neurodegenerative disease in old age, which not only affects the patient’s thinking, memory and independence, but also leads to a decline in the quality of […]