BOC Sciences Blog

structure and mechanism of action of antibody conjugated drugs

ADC Linker-The key from mAb to ADC

Antibody conjugated drug (ADC) is a relatively complex molecule that connects a targeted antibody with a cytotoxic payload through a chemical linker. In recent years, people have gradually deepened their research on payload and […]

Research and clinical progress in RNA therapy

RNA-based therapeutics The Human Genome Project (HGP) has revealed a wealth of information about the human genome and has greatly enhanced its role in the development of biomedical research. Thanks […]

Nucleic Acid Drugs

siRNA vs ASO: Small Nucleic Acid Drugs Revolution Unleashed

In recent years, small nucleic acid drugs have emerged as a focal point in biomedical research due to their strong specificity, simple design, short development cycles, and diverse target options. […]

tRNA

tRNA Therapy: A New Option in the Age of mRNAs

In recent years, rapid advancements in gene therapy have brought about a significant transformation in modern medicine. The application of advanced molecular biology techniques and enhanced delivery systems has ushered […]

Covalent Inhibitors

Covalent Inhibitors Targeting Undruggable Protein

With the rise of genomics and proteomics, many clinically significant targets have been discovered in human diseases. However, a relatively small proportion of traditional druggable targets exists, and many targets […]

antibody-drug conjugates

Progress in Analysis of Neutralizing Activity of ADC Anti-drug Antibodies

Antibody drug conjugates (ADCs) are multi-domain molecules composed of monoclonal antibodies, linkers and small molecule cytotoxins. ADCs specifically bind target antigens highly expressed on the surface of tumor cells through monoclonal antibodies, enter […]

cmc

CMC Regulatory Considerations for ADCs

Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs […]

microbial production

Microbial Production of Bio-based Plastics

At the 5th United Nations Environment Assembly (UNEA-5) held in March 2022, 175 countries signed a resolution to end plastic pollution. The aim is to achieve a legally binding international agreement […]

mRNA technologies

Effect of Codons and Secondary Structure on mRNA Protein Expression Levels

mRNA serves as templates for creating proteins, and the quantity of protein generated from each mRNA molecule is contingent on how the translation apparatus commences or elongates the coding sequence (CDS). Additionally, […]

ADC Target

ADC Therapeutic Targets in Breast Cancer

Breast cancer is the leading cause of death among women worldwide. When breast cancer spreads to other parts of the body, the prognosis is poor. Currently, there is no treatment […]