BOC Sciences Blog

Covalent, Non-covalent, and Covalent Reversible Drug Design in Medicinal Chemistry

Covalent, Non-covalent, and Covalent Reversible Drug Design in Medicinal Chemistry

Chemical drugs can be classified into three categories based on their binding modes: covalent drugs, non-covalent drugs, and covalent reversible drugs. Covalent drugs have strong binding ability and high efficacy, […]

Research progress on adjuvants for influenza vaccines

Research Progress on Adjuvants for Influenza Vaccines

Influenza is an acute and highly contagious respiratory disease caused by influenza A and B viruses. Annual influenza epidemics are caused by several different seasonal influenza viruses (i.e., A/H1N1, A/H3N2, B/Yamagata, […]

Types of Delivery Systems of mRNA Cancer Vaccines

Types of Delivery Systems of mRNA Cancer Vaccines

Brief Description of mRNA Delivery Systems As a therapeutic use, mRNA cancer vaccines have the advantages of high safety, strong immune activation ability, and short production cycle. Moreover, mRNA cancer […]

Review of Popular Targets

Review of Popular Targets

In recent years, antibody therapies (including traditional antibodies and nano-antibodies) have become an important means of treating a wide range of human malignant diseases, and more than 100 antibody therapies […]

Design Ideas for FDA-Approved Small Molecule Drugs in the third quarter of 2023

Design Ideas for FDA-Approved Small Molecule Drugs in the third quarter of 2023

FDA approved the marketing of 14 drugs in the third quarter of 2023, including 6 small molecule drugs. This article mainly focuses on the drug design ideas of small molecule drugs, hoping […]

Research progress on aluminum adjuvants and their mechanisms of action

Research progress on aluminum adjuvants and their mechanisms of action

What is Adjuvants? Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response […]

structure and mechanism of action of antibody conjugated drugs

ADC Linker-The key from mAb to ADC

Antibody conjugated drug (ADC) is a relatively complex molecule that connects a targeted antibody with a cytotoxic payload through a chemical linker. In recent years, people have gradually deepened their research on payload and […]

Research and clinical progress in RNA therapy

RNA-based therapeutics The Human Genome Project (HGP) has revealed a wealth of information about the human genome and has greatly enhanced its role in the development of biomedical research. Thanks […]

Nucleic Acid Drugs

siRNA vs ASO: Small Nucleic Acid Drugs Revolution Unleashed

In recent years, small nucleic acid drugs have emerged as a focal point in biomedical research due to their strong specificity, simple design, short development cycles, and diverse target options. […]

tRNA

tRNA Therapy: A New Option in the Age of mRNAs

In recent years, rapid advancements in gene therapy have brought about a significant transformation in modern medicine. The application of advanced molecular biology techniques and enhanced delivery systems has ushered […]