Celastrol, a quinine methide triterpene extracted from the perennial vine Tripterygium wilfordii (Celastraceae), has been used in traditional Chinese medicine as a natural remedy for inflammation and a variety of […]
The regulation of gene expression is based on the sequence selective recognition of nucleic acids by a host of repressor, activator, and enhancer proteins. Selective external disruption or control of […]
Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which nicotinamide is converted into NAD. In fact, nicotinamide or nicotinamide riboside derived from degradation of NAD can be […]
Nicotinamide adenine dinucleotide (NAD) has versatile functions in all cells. Besides its involvement in energy metabolism it serves important functions as substrate in a variety of cellular signaling reactions. Although […]
Arsenic toxicity and its association with human diseases such as blackfoot disease, diabetes, hypertension and some kinds of cancers have been widely considered in the literature. It is well known […]
N-(2,4-Dinitrophenyl)tetrapeptide p-nitroanilides (Dnp-tetra-peptide-pNA) exhibit characteristic CD spectra when they take on β-turn conformation. Exciton coupling of electric transition dipoles of the two chromophores is thought to be the origin of […]
The horseradish peroxidase (HRP)-catalyzed chemiluminescent oxidation of luminol is widely used in many molecular biology-based assays, such as Western blots, dot blots, and enzyme-linked immunosorbent assays (ELISAs), as well as […]
Favipiravir (T-705) is a nucleoside analog that was recently approved as an anti-influenza drug in Japan, and is in Phase 3 clinical trials in the USA for the same indication. […]
A number of BZ anthelmintics used in veterinary medicine have been considered for transition to human use, including oxibendazole and oxfendazole (OXF). In addition, flubendazole, already approved for use as […]
João Ricardo de Souza Martins and co-workers described the first report of fluazuron resistance in R. microplus, and also report the first tick strain that was multi-resistant to six classes […]