BOC Sciences Blog

Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses

Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses

Favipiravir (T-705) is a nucleoside analog that was recently approved as an anti-influenza drug in Japan, and is in Phase 3 clinical trials in the USA for the same indication. […]

Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies

Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies

A number of BZ anthelmintics used in veterinary medicine have been considered for transition to human use, including oxibendazole and oxfendazole (OXF). In addition, flubendazole, already approved for use as […]

First report of fluazuron resistance in Rhipicephalus microplus: A field tick population resistant to six classes of acaricides

First report of fluazuron resistance in Rhipicephalus microplus: A field tick population resistant to six classes of acaricides

João Ricardo de Souza Martins and co-workers described the first report of fluazuron resistance in R. microplus, and also report the first tick strain that was multi-resistant to six classes […]

Development of albendazole sulfoxide-loaded Eudragit microparticles: A potential strategy to improve the drug bioavailability

Development of albendazole sulfoxide-loaded Eudragit microparticles: A potential strategy to improve the drug bioavailability

Benzimidazole compounds are especially effective against nematodes found in the gastrointestinal tube in combating adult worms besides their larvae and eggs. They are also highly effective against lung worms. Their […]

Role of excipients in the crystallization of Albendazole Has Been Reported

Role of excipients in the crystallization of Albendazole Has Been Reported

Mihir K. Raval and coworkers reported cocrystallization of Albendazole. Cocrystallization approach with solvent evaporation technique at room temperature has been utilized to improve the physicochemical and mechanical properties of albendazole […]

Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine

Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine

Background: Lumefantrine, a commonly used antimalarial drug, inhibits hemozoin formation in parasites. Several other antimalarial substances counteract parasitemia by triggering suicidal death or eryptosis of infected erythrocytes. Eryptosis is characterized […]

Total synthesis of avermectin B1a revisited

Total synthesis of avermectin B1a revisited

Total synthesis of avermectin B1a revisited was achieved by Masahiro Hirama and co-workers in Tohoku University in Japan. Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by Ōmura […]

NSI-189 Was Found Highly Potential to be Antidepressant

NSI-189 Was Found Highly Potential to be Antidepressant

A phase 1b clinical trial aimed to examine the tolerability and efficacy of NSI-189 was conducted in 2014 and the study paper is available recently for the exact study results. […]

A Look at the Report of Globe Non-Tyrosine Kinase Inhibitor in Oncology, 2015-2025

A Look at the Report of Globe Non-Tyrosine Kinase Inhibitor in Oncology, 2015-2025

The report of non-tyrosine kinase inhibitor market in oncology in the period of 2015 to 2025 was released early in April of this year. Some of the data mentioned in […]

How to Dispose the Waste from Isotope Labeling

How to Dispose the Waste from Isotope Labeling

Isotope labeling has been widely used in various studies and practice, much more attention is paid on its application and technology advancement, the disposal of the related waste is ignored. […]