Salcaprozate sodium (SNAC) (sodium 8-((2-hydroxybenzoyl)amino) octanoate, CAS RN 203787-91-1) is classified as an oral absorption promoter. Although several clinical investigations have explored the potential therapeutic applications of Salcaprozate sodium (SNAC) as […]
A number of endogenous systems exist to counter the effects of vasoconstricting neurohormones that are increased in congestive heart failure (CHF). These include natriuretic peptides, nitric oxide, and prostaglandins. A […]
The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic […]
Celastrol, a quinine methide triterpene extracted from the perennial vine Tripterygium wilfordii (Celastraceae), has been used in traditional Chinese medicine as a natural remedy for inflammation and a variety of […]
The regulation of gene expression is based on the sequence selective recognition of nucleic acids by a host of repressor, activator, and enhancer proteins. Selective external disruption or control of […]
Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which nicotinamide is converted into NAD. In fact, nicotinamide or nicotinamide riboside derived from degradation of NAD can be […]
Nicotinamide adenine dinucleotide (NAD) has versatile functions in all cells. Besides its involvement in energy metabolism it serves important functions as substrate in a variety of cellular signaling reactions. Although […]
Arsenic toxicity and its association with human diseases such as blackfoot disease, diabetes, hypertension and some kinds of cancers have been widely considered in the literature. It is well known […]
N-(2,4-Dinitrophenyl)tetrapeptide p-nitroanilides (Dnp-tetra-peptide-pNA) exhibit characteristic CD spectra when they take on β-turn conformation. Exciton coupling of electric transition dipoles of the two chromophores is thought to be the origin of […]
The horseradish peroxidase (HRP)-catalyzed chemiluminescent oxidation of luminol is widely used in many molecular biology-based assays, such as Western blots, dot blots, and enzyme-linked immunosorbent assays (ELISAs), as well as […]