Glioblastoma multiforme (GBM) is the most malignant primary human brain cancer and cannot be cured by any therapy available today. Current therapy includes complex treatments of neurosurgical resection, radiotherapy, and […]
Pharmaceutical industry is growing day by day with the aim to develop new drugs extracted from natural products or synthetic chemically produced drug substances, but one thing always remains constant, […]
A biowaiver monograph of pyrazinamide based on literature data together with some additional experimental data is presented. The risks of basing a bioequivalence (BE) assessment on in vitro rather than […]
The study of carbamazepine solid forms continues to be a forum for advancing fundamental knowledge about polymorphism, hydrate formation, crystal engineering of pharmaceuticals, and structure–property relationships of pharmaceutical relevance. The […]
Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is characterized by a progressive loss of memory associated with other cognitive sphere deficits interfering with social and occupational functioning. The […]
The majority of inflammatory bowel disease (IBD) consists of two related but clinically and histologically distinct conditions, ulcerative colitis and Crohn’s disease. Both conditions are characterized by chronically relapsing inflammation […]
In recent years, significant efforts have been devoted to the development of amphiphilic polymers consisting of hydrophilic polysaccharides and hydrophobic moieties because of their ability to form nanoparticle self-assemblies in […]
Albendazole is a member of the benzimidazole group of anthelmintics with broad-spectrum activity against gastro-intestinal roundworms including inhibited larval stages, tapeworms, liver flukes and lungworms in many species. In the […]
Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists
The vertebrate orexin neuropeptide–receptor system plays a pivotal role in the regulation of sleep and wake states as well as emotional states related to stress or reward. The neuropeptides orexin […]
Small-molecule modulators of the Sonic Hedgehog signaling pathway Shh pathway inhibition with non-naturally occurring small molecules Cell-based assays with reporter gene constructs have been widely used for discovering non-naturally occurring […]