Eradication of hepatitis C virus (HCV) infection is extremely important to either cure hepatitis or prevent the progression of hepatic fibrosis and the development of hepatocellular carcinoma. Antiviral therapy using peginterferon and […]
Free radicals induce oxidative damage in vivo causing aging and various diseases. They are also the major cause for deterioration, quality loss, and shelf life reduction in oils/fats and fat-containing systems. There are […]
Renal cell cancer (RCC) is responsible for 3.7 % of all cancers diagnosed yearly and is ranked as the third most common urological cancer in the US population. The average age at diagnosis […]
Non-small cell lung cancer (NSCLC) is a leading cause of death among cancer patients. The 5-year overall survival rate in patients with localized cancer is 55.2 %, and this decreases to 4.3 % […]
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone which modulates cellular homeostasis and environmental stress responses by interacting with more than 200 proteins, also known as Hsp90 client proteins, […]
Cancer is primarily a disease of the older adult with more than 50 % of new cases occurring in adults older than 65 years. The care of older adults with cancer can […]
Immunotherapy and immune checkpoint inhibition in particular present an exciting opportunity for the treatment of bladder cancer. Over the last 30 years, bladder cancer patients have seen few advances in the […]
Ovarian cancer is a cancerous growth arising from numerous parts, mainly the outer lining of the ovary called germinal epithelium. It is the fifth leading cause of cancer-related death among women, which causes […]
The ability of the immune system to detect and eliminate cancer was first proposed over 100 years ago. Since then, T cells reactive against tumor-associated antigens have been detected in […]
Myelofibrosis (MF) includes primary MF and MF that has arisen from an antecedent polycythemia vera (PV) or essential thrombocythemia (ET) (post-PV/ET MF). MF can affect patients in various ways, including progressive splenomegaly, cytopenias (particularly […]