PCR additives play a crucial role in the PCR process, acting on various stages of the PCR reaction through different mechanisms, affecting amplification efficiency, specificity, and yield. The mechanisms of […]
Targeted Chimera Proteolysis (PROTAC) technology represents a breakthrough development in the field of drug discovery, utilizing the ubiquitin proteasome system to specifically degrade disease-associated proteins. PROTACs has a two-part function structure, that […]
Vaccines are one of the most important inventions in human history, which has revolutionized human life and health. Typically, vaccines work by triggering an innate immune response and stimulating antigen-presenting […]
In the first half of the year, the FDA approved a number of landmark drugs, and there are many highlights: Rezdiffra, the first non-alcoholic steatohepatitis drug in 40 years, was […]
In the development of immunoassay reagents, buffer is typically the second most critical factor after core materials. It can affect various fundamental properties of the reagents, such as stability, sensitivity, […]
The buffering capacity of HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer solution derives from its chemical structure and acid-base equilibrium properties. Specifically, its buffering capacity is due to the equilibrium reactions between the acidic […]
A disaccharide is an elementary form of carbohydrate that is necessary for the intricate web of metabolic processes that keep life alive. These molecules constitute the combination of two monosaccharide […]
Covalent inhibitors generally refer to irreversible covalent inhibitors; however, in detailed studies, they can be divided into irreversible covalent inhibitors (ICIs) and reversible covalent inhibitors (RCIs). Advantages of covalent inhibitors […]
The target spectrum and treatable diseases of small nucleic acid drugs are diverse. Relevant companies primarily focus on rare monogenic diseases with clear pathogenic mechanisms, well-defined biomarkers, and a lack […]
Molecular Glue refers to small molecules, typically smaller than PROTACs, often with improved physicochemical properties, designed to stabilize interactions between two proteins. In most cases, this approach is used to enhance […]