2-Mercaptobenzoimidazoles are an interesting class of heterocycles in medicinal chemistry as their core structure is part of different established therapeutics. The most prominent ones of these drugs are omeprazole, which acts as a […]
Sarcopenia was originally defined as the age-related loss of muscle mass. Subsequently, it became obvious to clinicians that it was muscle quality, rather than muscle mass that determined the function of muscle. This […]
Nuclear Hormone Receptors Nuclear hormone receptors are a super-family of evolutionarily conserved ligandregulated transcription factors that collectively direct genomic programs for a wide array of biological processes including reproduction, development, metabolism, circadian […]
A detailed mechanism of reaction has been proposed based on crystallography and site-directed mutagenesis data obtained for murine adenosine deaminase. The kinetic studies based on solvent isotope effects and measurements with halogen substituents […]
Since Ed Hall and colleagues first discovered that female gerbils were relatively protected from global cerebral ischemia, compared with their male counterparts, in the early 1990s (Hall et al., 1991), gender differences […]
Morphogenesis and cell polarity Changes in the morphology and polarity of cells are clearly essential for tumor progression and metastasis. In two-dimensional (2D) culture, it has been observed that oncogenic […]
Ras has been described to promote proliferation, suppress apoptosis, alter cell metabolism, disrupt morphogenesis, promote evasion of the immune system, induce remodeling of the microenvironment and stimulate metastasis. These functions are […]
The chemotherapy of cancer strongly depends on the nature of the individual tumor under consideration. For instance, tumors located in hormone dependent organs such as the ovaries, breasts, etc. are treated with […]
γ-Secretase is a multi-subunit protein complex that is composed of at least four proteins-Presenilin (PS), Nicastrin (Net), Presenilin-enhancer 2 (Pen2) and Anteriorpharyx defective (Aph). These four subunits form an active γ-Secretase complex in the […]
In cells, it has been shown that Syk becomes active after binding to the phosphorylated ITAMs located on the BCR. Syk binds the two ITAM phosphotyrosines through its tandem SH2 domains. Hydrogen/deuterium exchange […]