2-Mercaptobenzoimidazoles are an interesting class of heterocycles in medicinal chemistry as their core structure is part of different established therapeutics. The most prominent ones of these drugs are omeprazole, which acts as […]
In highly lipogenic tissues such as the liver, adipose and lactating breast, the Fatty acid synthase (FAS) catalyzed fatty acid synthesis pathway has three main functions: 1) the conversion of excess caloric intake […]
Converging evidence from numerous investigations suggests that the role of corticotropin-releasing factor (CRF) in modulating the neurobiological effects of ethanol is dependent on the duration of exposure. Generally, initial or acute exposures […]
Biologics have changed the landscape of therapy for rheumatoid arthritis (RA). While they have substantially improved outcomes in patients with RA who are disease-modifying antirheumatic drug (DMARD) incomplete responders (IRs), they require administration via […]
2-Mercaptobenzoimidazoles are an interesting class of heterocycles in medicinal chemistry as their core structure is part of different established therapeutics. The most prominent ones of these drugs are omeprazole, which acts as a […]
Sarcopenia was originally defined as the age-related loss of muscle mass. Subsequently, it became obvious to clinicians that it was muscle quality, rather than muscle mass that determined the function of muscle. This […]
Nuclear Hormone Receptors Nuclear hormone receptors are a super-family of evolutionarily conserved ligandregulated transcription factors that collectively direct genomic programs for a wide array of biological processes including reproduction, development, metabolism, circadian […]
A detailed mechanism of reaction has been proposed based on crystallography and site-directed mutagenesis data obtained for murine adenosine deaminase. The kinetic studies based on solvent isotope effects and measurements with halogen substituents […]
Since Ed Hall and colleagues first discovered that female gerbils were relatively protected from global cerebral ischemia, compared with their male counterparts, in the early 1990s (Hall et al., 1991), gender differences […]
Morphogenesis and cell polarity Changes in the morphology and polarity of cells are clearly essential for tumor progression and metastasis. In two-dimensional (2D) culture, it has been observed that oncogenic […]