In addition to DNA, peptides, as amino acid polymers, have great potential for information storage (Figure 1A). Recently, Stephen L. Buchwald and Bradley L. Pentelute of Massachusetts Institute of Technology (MIT) […]
CK1 functions Protein phosphorylation mediated by protein kinases is essential for the activation and deactivation of many signaling pathways in cells. As a result, abnormal protein kinase activity is frequently […]
Alzheimer’s disease (AD) is a complicated thing. Although amyloid-β (Aβ) is still considered to be the key to the pathogenesis of AD, which is supported by considerable evidence, the progression of […]
Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been discovered against more than […]
Drug screening is the initial link and key to drug development. In the past, traditional drug screening methods such as animal models were often costly and time-consuming. With the development […]
Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play central roles in regulating cell proliferation, survival, differentiation, and migration. Overexpression of […]
Fatty acids are essential for cell survival and function as biological energy substrates, structural components, and signaling molecules. Given their critical role, cells have evolved mechanisms to produce fatty acids from […]
As an alternative to surgery, radiotherapy, and chemotherapy, tumor therapy via the immune pathway has made significant advances in recent years. Among the targeted drugs of immuno-oncology (IO), Ab drugs […]
Integrins are cell adhesion and signaling proteins that play important roles in a wide range of biological functions. Currently, integrin-targeting drugs have been extensively developed in areas including cardiovascular disease, […]
In late 2014, the PARP inhibitor Olaparib was approved to treat ovarian cancer with BRCA mutations. Since then, research in the field of PARP has received extensive attention, especially in […]