Genotoxic impurities can directly act on DNA in the human body, causing DNA damage and having carcinogenic, teratogenic, or mutagenic properties. A small amount of genotoxic impurities can also cause great […]
The analysis of impurities in drugs is a very important part. This blog focuses on the important role of the source analysis of impurities and the development of analytical techniques in the […]
Overview of Suzuki coupling reaction In the entire Suzuki-coupling reaction cycle, the oxidation-addition reaction of Pd(0) with halogenated aromatics to produce the Pd(II) complex is considered to be the decisive […]
In recent years, antibody-drug conjugates (ADCs) have achieved substantial success in cancer therapy. Typically, an antibody or peptide in a conjugated drug acts as a precisely located “navigator” while a small-molecule […]
Summary Heterocyclic compounds with aromatic characteristics are called aromatic heterocyclic compounds, which can be classified into monoaromatic heterocycles and fused heterocycles. The common monoaromatic heterocycles are five-membered Furan, Pyrrole, Thiophene, Pyrazole, Imidazole, […]
Innovative drug research and development is a very complicated and risky process from discovery to marketing, which includes preclinical research, clinical trial application, clinical trial (also divided into clinical phases […]
In addition to DNA, peptides, as amino acid polymers, have great potential for information storage (Figure 1A). Recently, Stephen L. Buchwald and Bradley L. Pentelute of Massachusetts Institute of Technology (MIT) […]
CK1 functions Protein phosphorylation mediated by protein kinases is essential for the activation and deactivation of many signaling pathways in cells. As a result, abnormal protein kinase activity is frequently […]
Alzheimer’s disease (AD) is a complicated thing. Although amyloid-β (Aβ) is still considered to be the key to the pathogenesis of AD, which is supported by considerable evidence, the progression of […]
Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been discovered against more than […]