Albendazole is a member of the benzimidazole group of anthelmintics with broad-spectrum activity against gastro-intestinal roundworms including inhibited larval stages, tapeworms, liver flukes and lungworms in many species. In the […]
Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists
The vertebrate orexin neuropeptide–receptor system plays a pivotal role in the regulation of sleep and wake states as well as emotional states related to stress or reward. The neuropeptides orexin […]
Small-molecule modulators of the Sonic Hedgehog signaling pathway Shh pathway inhibition with non-naturally occurring small molecules Cell-based assays with reporter gene constructs have been widely used for discovering non-naturally occurring […]
The ADP-ribosyltranferase diphtheria toxin-like (ARTD) or poly-ADP-ribose polymerase (PARP) protein superfamily comprises 17 proteins that contain a common catalytic domain. Those that are catalytically active use β-NAD+ as an essential […]
Ya-tong-yi-li-wan (YTYLW) is a well-known traditional Chinese medicine (TCM) formula composed of ChanSu (toad venom), licorice root, realgar, and cinnabaris in the ratio of 24 : 24 : 6 : […]
Semi-synthetic glycopeptide antibiotics Oritavancin, telavancin and dalbavancin Early studies by Nagarajan et al. into the development of semi-synthetic glycopeptide antibiotics focused on utilizing vancomycin as a structural […]
N-(2,4-Dinitrophenyl)tetrapeptide p-nitroanilides (Dnp-tetra-peptide-pNA) exhibit characteristic CD spectra when they take on β-turn conformation. Exciton coupling of electric transition dipoles of the two chromophores is thought to be the origin of […]
A number of BZ anthelmintics used in veterinary medicine have been considered for transition to human use, including oxibendazole and oxfendazole (OXF). In addition, flubendazole, already approved for use as […]
João Ricardo de Souza Martins and co-workers described the first report of fluazuron resistance in R. microplus, and also report the first tick strain that was multi-resistant to six classes […]
Benzimidazole compounds are especially effective against nematodes found in the gastrointestinal tube in combating adult worms besides their larvae and eggs. They are also highly effective against lung worms. Their […]
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