In the early 21st century, after the completion of the Human Genome Project, it was discovered that many diseases were caused by gene mutations leading to insufficient expression of functional […]
The popularity of thiol coupling in ADC preparation can be attributed to three factors: It is essential to note that a reduction step is always required before coupling to release […]
Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of […]
Influenza is an acute and highly contagious respiratory disease caused by influenza A and B viruses. Annual influenza epidemics are caused by several different seasonal influenza viruses (i.e., A/H1N1, A/H3N2, B/Yamagata, […]
The Background of mRNA Vaccines At the beginning of 2020, the COVID-19 outbreak occurred. To establish a protective barrier against the pandemic, it was essential to rapidly develop safe and effective vaccines. mRNA vaccines […]
Antibody-Drug Conjugates (ADCs) are new therapies that combine the high targeting of monoclonal antibodies with the strong cytotoxicity of small molecule cytotoxins. Due to its precise and powerful mechanism of action, […]
It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB). This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a […]
Antibody-drug conjugate (ADC) combines the tumor targeting specificity of monoclonal antibodies and the potent cell killing activity of cytotoxic drugs (warhead/payload), through a carefully designed chemical linker (linker). The two are […]
Many approaches have been developed to improve the physical/chemical properties, potency and selectivity of antibody-drug conjugates (ADCs). Trastuzumab (Tz), a monoclonal antibody targeting HER2, was approved by the FDA in […]
A conjugate vaccine is a type of vaccine that combines a weak or non-toxic part of a disease-causing microorganism (such as a bacteria or virus) with a carrier protein. The […]