In recent years, with the continuous advancements in protein gene engineering and chemical conjugation technologies, the field of conjugated drugs has seen a blooming of diverse concepts, resulting in a […]
Ribonucleic acid (RNA) plays a critical role in cellular diversity and gene expression and may offer more drug targets than proteins. However, due to their small size and relatively poor […]
Targeted Chimera Proteolysis (PROTAC) technology represents a breakthrough development in the field of drug discovery, utilizing the ubiquitin proteasome system to specifically degrade disease-associated proteins. PROTACs has a two-part function structure, that […]
Molecular Glue refers to small molecules, typically smaller than PROTACs, often with improved physicochemical properties, designed to stabilize interactions between two proteins. In most cases, this approach is used to enhance […]
Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in cells participate in nearly all life […]