Oligonucleotides have shown efficient therapeutic effects in various fields, indicating their potential for disease treatment. However, due to poor in vivo stability, ineffective cellular uptake, and off-target effects including immune stimulation, […]
As a vital drug modality, the field of oligonucleotide development will continue to expand and strengthen in the coming years. Oligonucleotide therapeutics are a class of medicines composed of short […]
The main challenge in RNA and other nucleic acid-based therapeutics is how to deliver genetic information to target cells in the body. This barrier is currently being addressed, partly due […]
Structure of nucleic acids is a big concept in biophysics. Nucleic acid structure is multi-level, multi-complex and unified: Primary, secondary, tertiary and quaternary structures constitute the full spatial conformation and […]
What are the gene therapies? Following Stanfield Rogers’s 1970 discovery of using “good” deoxyribonucleic acid (DNA) to replace faulty DNA in hereditary disorders, the idea of gene therapy for human […]
What are oligonucleotides? Oligonucleotides, which cover both deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are increasingly demonstrating their central value in clinical practice. A notable example is the introduction of […]
PCR additives play a crucial role in the PCR process, acting on various stages of the PCR reaction through different mechanisms, affecting amplification efficiency, specificity, and yield. The mechanisms of […]
The target spectrum and treatable diseases of small nucleic acid drugs are diverse. Relevant companies primarily focus on rare monogenic diseases with clear pathogenic mechanisms, well-defined biomarkers, and a lack […]
Aptamers are short RNA/DNA oligonucleotide molecules that bind specifically to complementary target molecules. As potential recognition elements, aptamers show promising applications in both diagnosis and treatment. They offer diverse therapeutic and diagnostic […]
RNA-based therapeutics The Human Genome Project (HGP) has revealed a wealth of information about the human genome and has greatly enhanced its role in the development of biomedical research. Thanks […]