Apoptosis Definition: Apoptosis refers to a highly organized, gene-controlled process in which cells actively undergo death. It plays a crucial role in maintaining tissue homeostasis and eliminating damaged, aging, or […]
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by intestinal L cells in response to dietary intake. Within minutes after a meal, GLP-1 is released from the L cells in the […]
For a drug to exert its effect, it must bind to the corresponding target. Drug targets mainly include enzymes, receptors, ion channels, hormones, and cytokines. Small molecules that bind to […]
Covalent inhibitors generally refer to irreversible covalent inhibitors; however, in detailed studies, they can be divided into irreversible covalent inhibitors (ICIs) and reversible covalent inhibitors (RCIs). Advantages of covalent inhibitors […]
CD137/4-1BB combination therapy
In recent years, antibody therapies (including traditional antibodies and nano-antibodies) have become an important means of treating a wide range of human malignant diseases, and more than 100 antibody therapies […]
FDA approved the marketing of 14 drugs in the third quarter of 2023, including 6 small molecule drugs. This article mainly focuses on the drug design ideas of small molecule drugs, hoping […]
With the rise of genomics and proteomics, many clinically significant targets have been discovered in human diseases. However, a relatively small proportion of traditional druggable targets exists, and many targets […]
In 2007, Japanese professors firstly discovered ALK rearrangement and identified the fusion of ALK and EML4 in non-small cell lung cancer specimens. EML4 can promote the activation of ALK kinase […]
CDKs belong to the serine/threonine protein kinase family, and their kinase activity requires binding to cyclins. Abnormalities in CDKs have been reported to cause proliferation, genomic and chromosomal instability that […]