Metabolic syndrome refers to a class of complex metabolic disorders, including adipose tissue accumulation, insulin resistance, diabetes, hyperinsulinemia, hypertension, and dyslipidemia, characterized by high levels of triglycerides (TG) and high-density […]
Globally, the COVID-19 pandemic has significantly accelerated the development of mRNA technology platforms and mRNA industry chains. The first mRNA drug (BNT162b2 vaccine) was granted emergency use authorization by the […]
The analysis of impurities in drugs is a very important part. This blog focuses on the important role of the source analysis of impurities and the development of analytical techniques in the […]
In recent years, antibody-drug conjugates (ADCs) have achieved substantial success in cancer therapy. Typically, an antibody or peptide in a conjugated drug acts as a precisely located “navigator” while a small-molecule […]
Innovative drug research and development is a very complicated and risky process from discovery to marketing, which includes preclinical research, clinical trial application, clinical trial (also divided into clinical phases […]
In addition to DNA, peptides, as amino acid polymers, have great potential for information storage (Figure 1A). Recently, Stephen L. Buchwald and Bradley L. Pentelute of Massachusetts Institute of Technology (MIT) […]
CK1 functions Protein phosphorylation mediated by protein kinases is essential for the activation and deactivation of many signaling pathways in cells. As a result, abnormal protein kinase activity is frequently […]
Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been discovered against more than […]
Drug screening is the initial link and key to drug development. In the past, traditional drug screening methods such as animal models were often costly and time-consuming. With the development […]
Fatty acids are essential for cell survival and function as biological energy substrates, structural components, and signaling molecules. Given their critical role, cells have evolved mechanisms to produce fatty acids from […]