The core technologies of oligonucleotide drug development include sequence design, synthesis and modification, isolation and purification, and delivery techniques. The production of oligonucleotide raw materials adopts solid-phase synthesis technology, with […]
Metabolic syndrome refers to a class of complex metabolic disorders, including adipose tissue accumulation, insulin resistance, diabetes, hyperinsulinemia, hypertension, and dyslipidemia, characterized by high levels of triglycerides (TG) and high-density […]
Globally, the COVID-19 pandemic has significantly accelerated the development of mRNA technology platforms and mRNA industry chains. The first mRNA drug (BNT162b2 vaccine) was granted emergency use authorization by the […]
The analysis of impurities in drugs is a very important part. This blog focuses on the important role of the source analysis of impurities and the development of analytical techniques in the […]
In recent years, antibody-drug conjugates (ADCs) have achieved substantial success in cancer therapy. Typically, an antibody or peptide in a conjugated drug acts as a precisely located “navigator” while a small-molecule […]
Innovative drug research and development is a very complicated and risky process from discovery to marketing, which includes preclinical research, clinical trial application, clinical trial (also divided into clinical phases […]
In addition to DNA, peptides, as amino acid polymers, have great potential for information storage (Figure 1A). Recently, Stephen L. Buchwald and Bradley L. Pentelute of Massachusetts Institute of Technology (MIT) […]
CK1 functions Protein phosphorylation mediated by protein kinases is essential for the activation and deactivation of many signaling pathways in cells. As a result, abnormal protein kinase activity is frequently […]
Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been discovered against more than […]
Drug screening is the initial link and key to drug development. In the past, traditional drug screening methods such as animal models were often costly and time-consuming. With the development […]