With the rise of genomics and proteomics, many clinically significant targets have been discovered in human diseases. However, a relatively small proportion of traditional druggable targets exists, and many targets […]
Antibody drug conjugates (ADCs) are multi-domain molecules composed of monoclonal antibodies, linkers and small molecule cytotoxins. ADCs specifically bind target antigens highly expressed on the surface of tumor cells through monoclonal antibodies, enter […]
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs […]
Breast cancer is the leading cause of death among women worldwide. When breast cancer spreads to other parts of the body, the prognosis is poor. Currently, there is no treatment […]
Introduction of Oligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), […]
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis […]
Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial role in the innate immune system’s defense against microbial […]
Glycosylation is a complex form of post-translational modification that affects more than 50% of cellular proteins and is a key regulator of many eukaryotic processes. Aberrant glycosylation is a common […]
The Background of mRNA Vaccines At the beginning of 2020, the COVID-19 outbreak occurred. To establish a protective barrier against the pandemic, it was essential to rapidly develop safe and effective vaccines. mRNA vaccines […]
It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB). This is because the BBB is a highly selective biological barrier composed of specialized types of endothelial cells that form a […]