Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone which modulates cellular homeostasis and environmental stress responses by interacting with more than 200 proteins, also known as Hsp90 client proteins, […]
Myelofibrosis (MF) includes primary MF and MF that has arisen from an antecedent polycythemia vera (PV) or essential thrombocythemia (ET) (post-PV/ET MF). MF can affect patients in various ways, including progressive splenomegaly, cytopenias (particularly […]
The drive to compete and win is as old as humankind. Throughout history, athletes have sought foods and potions to enhance physical performance. Stimulants were one of the first groups of substances which […]
As a member of the prostamide class of ocular hypotensives, bimatoprost (Lumigan®) lowers intraocular pressure (IOP) by a dual mechanism: by increasing both pressure-dependent (presumed trabecular meshwork) and pressure-independent (presumed […]
Prostate cancer develops in the prostate, which is a gland in the male reproductive system. Prostate cancers generally grow slowly. However, aggressive prostate cancers do occur, which are capable of […]
Acute and chronic airways diseases represent a large proportion of the inpatient and outpatient population continuously under the care of pulmonary physicians and primary healthcare providers. This review article aims […]
Idebenone (2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone) is a synthetic analogue of ubiquinone, an essential constituent of the electron transport chain and a vital cell membrane anti-oxidant. It has been shown that patients with Friedreich […]
In Australia, the lifetime risk of developing non-melanoma skin cancer such as basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) is almost 70% for men and 60% for women. […]
Glioblastoma multiforme (GBM) is the most malignant primary human brain cancer and cannot be cured by any therapy available today. Current therapy includes complex treatments of neurosurgical resection, radiotherapy, and […]
Pharmaceutical industry is growing day by day with the aim to develop new drugs extracted from natural products or synthetic chemically produced drug substances, but one thing always remains constant, […]