A dynamic microwave-assisted extraction (DMAE) method is established for the extraction of total ginsenosides from ginseng fibrous roots. The extraction process has been simulated and its main affection factors (liquid/solid ratio K of […]
Treosulfan is an alkylating agent that is structurally related to busulfan. It is used in the treatment of ovarian carcinoma and currently considered in clinical trials as a conditioning agent prior to autologous […]
Brain metastasis (BM) is a common complication of lung cancer, and is usually associated with a dismal outcome within a few weeks or months. Non-small cell lung cancer (NSCLC) comprises about 75% of […]
2-Mercaptobenzoimidazoles are an interesting class of heterocycles in medicinal chemistry as their core structure is part of different established therapeutics. The most prominent ones of these drugs are omeprazole, which acts as […]
Biologics have changed the landscape of therapy for rheumatoid arthritis (RA). While they have substantially improved outcomes in patients with RA who are disease-modifying antirheumatic drug (DMARD) incomplete responders (IRs), they require administration via […]
Sarcopenia was originally defined as the age-related loss of muscle mass. Subsequently, it became obvious to clinicians that it was muscle quality, rather than muscle mass that determined the function of muscle. This […]
Nuclear Hormone Receptors Nuclear hormone receptors are a super-family of evolutionarily conserved ligandregulated transcription factors that collectively direct genomic programs for a wide array of biological processes including reproduction, development, metabolism, circadian […]
A detailed mechanism of reaction has been proposed based on crystallography and site-directed mutagenesis data obtained for murine adenosine deaminase. The kinetic studies based on solvent isotope effects and measurements with halogen substituents […]
Since Ed Hall and colleagues first discovered that female gerbils were relatively protected from global cerebral ischemia, compared with their male counterparts, in the early 1990s (Hall et al., 1991), gender differences […]
The chemotherapy of cancer strongly depends on the nature of the individual tumor under consideration. For instance, tumors located in hormone dependent organs such as the ovaries, breasts, etc. are treated with […]