Drug Discovery

SARS

Progress in R&D of Small Molecule Anti-COVID-19 Drugs (1)

The Coronavirus outbreak has posed a great threat to human health. Facing the continuous mutation of Coronavirus, researchers are working hard to develop effective and broad-spectrum anti-COVID-19 drugs as well […]

drug

Approved Carbohydrate-based Drugs During 2000-2021

As the basic substance of life, carbohydrate molecules participate in almost all aspects of life activities and play various important biological functions. Based on the extensive biological functions of carbohydrate, […]

Nanocarrier Systems for Nucleic Acid Drug Delivery

Nanocarrier Systems for Nucleic Acid Drug Delivery

Compared with conventional drugs, nucleic acids have great advantages. The mechanism of action and high specificity of nucleic acids provide possible therapeutic approaches for viral infections, various cancers and inoperable […]

The Development of Small-molecule Inhibitors Targeting CD47

The Development of Small-molecule Inhibitors Targeting CD47

Abstract Immunotherapy has become an indispensable part of cancer treatment. A pivotal phagocytosis checkpoint, named cluster of differentiation 47 (CD47), which functions as a ‘don’t eat me’ signal to protect […]

ADC linker

Types of ADC Linkers

The development of antibody-drug conjugates (ADCs) has progressed significantly over the past decade due to improvements in payloads, linkers, and conjugation methods. In particular, linker design plays a key role […]

drug

Three Basic Drug Delivery Methods

Drug Modification Drug modification involves altering the chemical structure of the drug itself (such as functional groups, amino acids or nucleic acid skeletons) and coupling the drug with known partial […]

Old woman with Alzheimer

What is Drugs Target Dopamine Receptor?

Background of Dopamine and Its Receptors In 1957, the Swedish scientist Arvid Carlsson first discovered dopamine and proposed that dopamine is not only a precursor of norepinephrine, it is also […]

New Technologies and Methods in Small Molecule Drug Development

Compared with biological drugs, small molecule drugs have greater advantages in R&D cost and process maturity, and they are still the main battlefield for drug research and development. According to […]

FDA-Approved Nucleic Acid Drugs

With the continuous development of molecular biology technology, the relationship between gene mutations and diseases has gained more and more in-depth understanding. Nucleic acids have attracted much attention because of […]

Strategies to Enhance Oligonucleotide Drug Delivery

1. Chemistry Modification Chemical modification represents one of the most effective approaches to enhance oligonucleotide drug delivery. Modification of the nucleic acid backbone, the ribose sugar moiety and the nucleobase […]