For a long time, the poor solubility and low bioavailability of APIhave been a major problem for drug developers, and the low solubility has led to the limitation of its […]
In the first half of the year, the FDA approved a number of landmark drugs, and there are many highlights: Rezdiffra, the first non-alcoholic steatohepatitis drug in 40 years, was […]
In the process of small molecule drug development, lipophilicity (or hydrophobicity) is a very important indicator that has a crucial impact on pharmacokinetics and pharmacodynamics. Lipophilicity involves the pharmacokinetic processes […]
The Drug-to-Antibody Ratio (DAR) is the most important quality attribute of ADC drugs because it determines the “payload” that can be delivered to tumors, directly impacting safety and efficacy. Here, we […]
In the early 21st century, after the completion of the Human Genome Project, it was discovered that many diseases were caused by gene mutations leading to insufficient expression of functional […]
Driven by increasingly mature technologies, ADC payloads have undergone three generations of innovation. In the first generation of ADC drugs, traditional chemotherapy agents such as methotrexate, vincristine, and doxorubicin were used […]
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the […]
Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. […]
With the rapid development of biotechnology and molecular medicine, the introduction of mRNA as a vaccine or therapeutic agent enables the production of almost any desired functional protein/peptide within the […]
Aptamers are short RNA/DNA oligonucleotide molecules that bind specifically to complementary target molecules. As potential recognition elements, aptamers show promising applications in both diagnosis and treatment. They offer diverse therapeutic and diagnostic […]