Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. […]
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, […]
Chemical drugs can be classified into three categories based on their binding modes: covalent drugs, non-covalent drugs, and covalent reversible drugs. Covalent drugs have strong binding ability and high efficacy, […]
Using synthetic biology methods allows for the more efficient production of highly complex drug molecules compared to traditional chemical methods, with increased stability and controllability. Many drug components are currently […]
Among the first-generation ADC drugs, traditional chemotherapy drugs such as methotrexate, vinblastine, and doxorubicin were used as cytotoxic payloads. However, due to insufficient cytotoxicity and selectivity against tumor cells, the first-generation […]
The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal […]
PROTACs, a novel therapeutic approach, have garnered interest from numerous pharmaceutical companies, including Merck, Genentech, Pfizer, Novartis, Arvinas, C4 Therapeutics, Haisco Pharmaceutical, Kintor Pharmaceutical, and BeiGene. Currently, approximately 20 PROTACs […]
Antibody-Drug Conjugates (ADCs) are new therapies that combine the high targeting of monoclonal antibodies with the strong cytotoxicity of small molecule cytotoxins. Due to its precise and powerful mechanism of action, […]
PEG-Lipid derivatives have the advantages of increasing the stability of liposomes, extending the half-life of blood circulation, improving tumor targeting efficiency and enhancing drug efficacy. In-depth study of the effects of […]
The emergence of RNA synthesis in vitro and in vivo delivery methods has garnered significant attention in the biomedical field, particularly regarding the applications of synthetic mRNA. However, in most biological […]